Drug Security Forum

The causes and mechanisms of a whole range of complex multifactorial diseases such as cancer, diabetes, Alzheimer’s disease, and autoimmune and metabolic conditions are now known. Reductionist medicine, focused on identifying the ‘main’ cause of disease and the areas for therapeutic action, is a thing of the past. The precise mechanisms of the orchestration of events leading to pathologies and endogenous factors contributing to the progression of a disease are already known. The depth of this knowledge opens the door to precision medicine, in which it is possible to select treatment strategies based on the specific current mechanisms of how an illness develops, what course it takes, and the precise molecular profile. Moreover, by taking into account the physiology, environment, lifestyle factors and history of each individual patient, personalized approaches tailored to each patient are possible as part of precision medicine. This paradigm necessitates a change in the principles of clinical research: conducting it in small groups of differentiated patients with particular characteristics. What actions and decisions are required of industry participants – regulators, developers, manufacturers, doctors, and patients – in the practice of precision medicine? Is the pharmaceutical industry prepared to differentiate its approaches to the development and introduction of different drug combinations and different approaches to a single disease? How will the transition to personalized medicine expand the market for medicines and revitalize approaches to treatment?

Moderator
Alexey Martynov, President, Association of Biomedical Cellular Products Manufacturers

Alexey Martynov

President, Association of Biomedical Cellular Products Manufacturers

Member of the Expert Council of the Business Projects Working Group of the Strategic Initiatives Agency
Member of the Commission on the pharmaceutical and medical industry of the Russian Union of Industrialists and Entrepreneurs
Education
Moscow Medical Academy named after Sechenov.
Qualification: Doctor with a specialization in "General Medicine".
2003 – 2006 г. State Scientific Center of Social and Forensic Psychiatry named after Serbsky.
Awarded specialty: "Psychiatrist".
2008 – 2012 г. the Russian Presidential Academy of the National Economy and Public Administration
Квалификация: Психолог. Преподаватель по специальности «Психология». Qualifications: Psychologist. The professor of "Psychology".
2009- 2010 г. International Academy of Acmeological Sciences
Effective interaction based on NLP (neuro-linguistic programming) technology.
2009 - 2010 г. Russian Academy of Public Administration under the President of the Russian Federation
"The psychological impact of professional activity."
2016 – 2018 "St. Petersburg State Chemical-Pharmaceutical Academy" of the Ministry of Health of the Russian Federation.
Master program "Regulation of the circulation of medicines in the pharmaceutical market"

Panellists
Alexey Belyaev, Director, National Medical Research Center of Oncology named after N.N. Petrov of the Ministry of Health of the Russian Federation
Danica Grujicic, Minister of Health of the Republic of Serbia
Andrey Kaprin, General Director, Federal State Budgetary Institution National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Сhief Freelance Specialist Oncologist of the Ministry of Health of the Russian Federation (online)
Dmitry Kudlay, Vice President for the Implementation of New Medical Technologies, Generium
Maria Makarova, Doctor, Evogen, Russian Scientific Center for Radiology
Evgeny Shlyakhto, General Director, Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation
Tatyana Yakovleva, First Deputy Head, Federal Medical-Biological Agency of the Russian Federation

Alexey Belyaev

Director, National Medical Research Center of Oncology named after N.N. Petrov of the Ministry of Health of the Russian Federation

D. M. Sc., Professor.
Director of the Federal State Budgetary Institution “N.N. Petrov National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation.
Since 2012 he is the Director of the Research Institute of Oncology.
Belyaev Aleksey Mikhaylovich is the main freelance oncologist of the Northwestern Federal District, Head of the Department of Oncology of the Mechnikov North-West State Medical University, Chairman of Oncologists Association of the Northwestern Federal District, Doctor of Medical Science, Professor.
Education:
1986 – graduated with honors and gold medal the “S.M. Kirov Military Medical Academy.”
1992 – postgraduate studies in a military college (graduate work) at the “S.M. Kirov Military Medical Academy”.
Research and practice activity:
1993 – passed the Ph.D. defense “Morphofunctional characteristics of soft tissues around of the gunshot wound (ballistic trauma)”
2004 – passed thesis for the doctor’s degree “Cytoreductive surgeries and hyperthermic intraperitoneal chemotherapy in the complex treatment of common forms of abdominal cancer”.
Since 1998 he has been developing problems of care for patients with advanced forms of peritoneal cancer. Belyaev Aleksey Mikhaylovich is one of the first in Russia, who began to perform cytoreductive surgeries with chemohyperpyretic perfusions of abdominal cavity. He is awarded the Diploma of the Ministry of Health of the Russian Federation and the Plaque “Excellent Worker of Public Health”, he has the Medal “For Merit to Domestic Health Care”.
Belyaev Aleksey Michaylovich is the author more than 200 research papers and one monograph. 10 Ph.D. defenses and 3 theses for a doctor degree were passed under his leadership.

Danica Grujicic

Minister of Health of the Republic of Serbia

Andrey Kaprin

General Director, Federal State Budgetary Institution National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Сhief Freelance Specialist Oncologist of the Ministry of Health of the Russian Federation

· Doctor of Medical Sciences, Professor, Academician of RAS, Honored Doctor of the Russian Federation.
· Director General of the National Medical Research Radiological Centre (NMRRC) of Ministry of Health of the Russian Federation, Director of the P.A. Herzen Moscow Cancer Research Institute, a branch of NMRRC.
· He is one of the leading specialists in the Russian Federation in the field of diagnosis and treatment of oncological diseases. Throughout the scientific and therapeutic activity, Andrey Kaprin conducts a purposeful development of modern methods of surgical and combined treatment of kidney, bladder, prostate and other localizations.
· Since 2014, Andrey Kaprin is heaing the first Russian scientific medical cluster in the field of oncology - the Federal State Budgetary Institution "National Medical Research Radiological Centre" of Ministry of Health of the Russian Federation, which was established on the basis of three leading medical centers - P. Herzen, A.Tsyb MRRC, and N. Lopatkin Research Institute of Urology and Interventional Radiology.
· At present, being the head of the NMRRC of Ministry of Health of the Russian Federation, being an academician of the Russian Academy of Sciences in oncoradiology, he supervises the development of nuclear medicine, radiology and radiotherapy in our country. He has taken charge of most complex and promising areas in the industry: the technical re-equipment of the radiation therapy departments of the regions, the creation of a program and a center for the development of contact methods of irradiation, the introduction and expansion of the first national medical proton center in the country, the introduction of modern methods of training specialists in radiology and radiotherapy, iIncluding telecommunication training and master classes in the regions, many of which are conducted by himself.
· Every year Andrey Kaprin performs over 300 complex surgical interventions for various oncological diseases.
· He has trained more than 300 doctors, including residents and graduate students. Under his leadership, 27 dissertations for the degree of candidate of medical sciences and 9 doctoral dissertations were prepared and successfully defended. The result of many years of hard work was the publication of more than 700 printed scientific works.

Dmitry Kudlay

Vice President for the Implementation of New Medical Technologies, Generium

MD, professor
Academic background
University: Medical University, Novosibirsk
Department and Qualification: General medicine, doctor
Professional background
1996 - 1999 – Director, the hospital of the Ministry of Internal Affairs, Novosibirsk
2000 - 2004 – Managing positions in Marketing & Promotion, Russian pharmaceutical industry
2004 - 2013 – Deputy General Director (Marketing & Promotion), PHARMSTANDARD (the largest Russian pharmaceutical company)
2013 - present – General director, GENERIUM
Membership and Awards
• Member of the Government Subcommittee on the Circulation of Medicines
• Member of the working group on the Eurasian Economic Commission drug market, MoH
• Member of the Expert Council for the Development of Pharmaceutical and Medical Industry, Ministry of Industry and Trade
• Member of European Respiratory Society
• Winner of the Russian Federation Government Award
Dmitry Kudlay is the author of more than 70 scientific articles in peer-reviewed Russian and foreign publications.

Maria Makarova

Doctor, Evogen, Russian Scientific Center for Radiology

Evgeny Shlyakhto

General Director, Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation

Professor Evgeny Shlyakhto, Director General of the Almazov National Medical Research Centre, Academician of the Russian Academy of Science, President of the Russian Society of Cardiology, Fellow of the European Society of Cardiology, the American Heart Association, and the American College of Cardiology.
Professor Shlyakhto was born on June 29, 1954 in Pogar, the Bryansk region. He graduated from the Pavlov Medical University in Saint Petersburg in 1977 and became Doctor of Science in Medicine in 1992, Professor in 1994, Honored Russian Scientist in 2004, and Academician of the Russian Academy of Sciences in 2014.
Evgeny Shlyakhto has been the Director General of the Almazov National Medical Research Centre since 2001 and the President of the Russian Society of Cardiology since 2011. In 2010, he became a member of the WHO Expert Working Group.
The Centre led by Prof. Shlyakhto carries out intensive research in the fields of translational medicine, molecular diagnostics, development of diagnostic tools for personalized treatment, cellular and tissue engineering for therapeutic purposes, creation of biocompatible materials and tissue-engineered constructs designed to create breakthrough medical technologies of fundamental importance for providing high-tech care to patients with cardiovascular, endocrine and blood diseases.
The results of research work by Prof. Shlyakhto have been summarized in more than 800 publications, 16 inventions, 2 scientific discoveries, and a number of monographs. Prof. Shlyakhto was a supervisor in 57 PhD and 20 DSc students..
Professor Shlyakhto is a member of the Presidium of the Russian Academy of Science, the Presidential Council for Science and Education, the Regional Health Council under the Federation Council of the Russian Federal Assembly, the Expert Health Council of the Federation Council Committee on Social Policy of the Russian Federal Assembly, Vice President of the National Medical Chamber.
Evgeny Shlyakhto is the Editor-in-Chief of the following medical journals: Russian Journal of Cardiology, Translational Medicine, and Journal of Arrhythmology. He also is a member of the international editorial board of the European Heart Journal.
Professor Shlyakhto plays an active role in such international committees as the ESC Congress Programme Committee (since 2012) and of the ESC Committee for Practice Guidelines (since 2015).
Evgeny Shlyakhto received the Russian Federation Government Prize in science and technology in 2009 and won the Pavlov Award, the prize for scientific and technological achievement in Physiology and Medicine from the Saint Petersburg Government and St. Petersburg Scientific Center of the Russian Academy of Sciences, in 2011. He received an Order of Honour in 2012 and 4th class Order of Merit for the Motherland in 2017.

Tatyana Yakovleva

First Deputy Head, Federal Medical-Biological Agency of the Russian Federation

Born 7 July 1960 in Goгky oblast.
In 1985, graduated Ivanovo State Medical Institute with honours, majoring in Paediatrics. Worked her way up from a rural hospital nurse to Chief Physician of Teykovo Central Regional Hospital (Ivanovo Oblast).
In 1999, elected Deputy of the 3rd State Duma of Ivanovo single member electoral district No.78 (Ivanovo oblast), also elected Deputy of the 4th, 5th, and 6th State Duma of the Federal Assembly of the Russian Federation.
Acted as Deputy Head of the State Duma Committee for Healthcare and Sports, Head of the State Duma Committee for Healthcare, First Deputy Head of the United Russia fraction at the State Duma of the Federal Assembly of the Russian Federation.
While in the State Duma, was a member of interagency working group on the Healthcare priority national project at the Russian Federation Presidential Council for the Implementation of the Priority National Projects, State Duma Committee for the Juvenile Affairs and Protection of their Rights and Governmental Committee for Combating Drug Abuse and Illegal Drug Trafficking, as well as acted as Deputy Head of State Duma Committee for Technical Regulation.
Doctor of Medicine, Honoured Doctor of the Russian Federation, Professor, co-author of over 59 research publications, 7 textbooks, 6 patents. The winner of the Russian Federation Governmental Award in the field of science and technology. In 2001, graduated Moscow State Social University specializing in Law. Holds top qualification category in Public Health. Chair of the Department on outpatient and social paediatrics at Pirogov Russian National Research Medical University (RNRMU), the Ministry of Health of the Russian Federation.
Decorated with the Order of Honour, Medal of the 2nd degree Order of Service to the Fatherland, Medal of Merit for the National Healthcare; received Citation from Valentina Matvienko, the Chair of the Federation Council of the Federal Assembly of the Russian Federation.
Appointed Deputy Minister of Healthcare of the Russian Federation by Government Order No.1010-р of 18 June 2012.

Front row participants
Timur Akhmerov, General Director, BARS Group
Vladimir Ivanov, Chief Executive Officer, Medgital
Sergey Kutsev, Director of the Federal State Budgetary Scientific Institution “Medical Genetic Research Center named after A.I. Academician N.P. Bochkov"; Chief Freelance Specialist in Medical Genetics of the Ministry of Health of Russia
Alexey Lundup, Director of the Scientific and Educational Resource Center for Cellular Technologies, Peoples' Friendship University of Russia

Timur Akhmerov

General Director, BARS Group

Sergey Kutsev

Director of the Federal State Budgetary Scientific Institution “Medical Genetic Research Center named after A.I. Academician N.P. Bochkov"; Chief Freelance Specialist in Medical Genetics of the Ministry of Health of Russia

In 1988, he graduated from the Medical Faculty of the Rostov Order of Peoples' Friendship Medical Institute (RODNMI). Upon graduation from the institute in 1988, he was left for postgraduate studies. In his main position from 1991 to 2000. - Assistant, from 2000 to 2006 - Associate Professor, and from 2006 to August 2011 - Head of the Laboratory of Medical Genetics at the Rostov State Medical University (RostSMU). From 2006, he was concurrently an associate professor and then professor of the course in genetics and laboratory genetics at the Faculty of Advanced Medical Education of the Rostov State Medical University.
After moving to Moscow in 2011 - as the head of the department at the Pirogov Russian National Research Medical University. From 2012 to 2015 - Deputy Head of the Mutagenesis Laboratory (part-time) at the Medical Genetics Research Center of the Russian Academy of Medical Sciences. From 2012 to 2015 - Deputy Director for Scientific Work of the Federal State Budgetary Scientific Institution "Moscow Research Center". From May 20, 2015 - Acting Director and then Director of the Federal State Budgetary Institution "Medical Genetics Research Center" (since 2019 - Federal State Budgetary Institution "Academician N.P. Bochkov Medical Genetics Research Center").
His scientific interests include clinic, diagnosis and treatment of inherited diseases, genetics of oncohematological diseases, the role of viruses in carcinogenesis, neonatal screening, and organization of medical genetic services. He is the author of more than 300 publications, 17 manuals and guidelines.

Alexey Lundup

Director of the Scientific and Educational Resource Center for Cellular Technologies, Peoples' Friendship University of Russia